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Table 2.

Clinical Characteristics of the Brain Data Set From the National NeuroAIDS Tissue Consortium

Data are mean ± SD or percentage (no.) of cases.

Abbreviations: CSF, cerebrospinal fluid; HIV, human immunodeficiency virus.

Global neurocognitive clinical rating was assessed as described elsewhere [ 32 ].

HIV-related neurocognitive disorder was assessed as described elsewhere [ 33 , 34 ].

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Table 2.

Clinical Characteristics of the Brain Data Set From the National NeuroAIDS Tissue Consortium

Data are mean ± SD or percentage (no.) of cases.

Abbreviations: CSF, cerebrospinal fluid; HIV, human immunodeficiency virus.

Global neurocognitive clinical rating was assessed as described elsewhere [ 32 ].

HIV-related neurocognitive disorder was assessed as described elsewhere [ 33 , 34 ].

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The protein abundance levels of the IBA1 marker were assessed as follows: 5-µm-thick, formalin-fixed, paraffin-embedded brain sections were immunostained with mouse monoclonal antibody against Iba-1 (Wako), as previously described [ 35 ]. The DAB-stained sections were digitally scanned using a microscopy slide scanner (Aperio ScanScope GL, Leica, Vista, California) equipped with a 20× objective lens (yielding the resolution of 0.5 µm/pixel). Anatomical areas of interest were digitally delineated and the immunoreactivity signals quantified within each of these areas using the Image-Pro Analyzer software (version 6.3; MediaCybernetics, Bethesda, Maryland), as previously described in detail [ 36 ].

Fresh frozen frontal lobe samples from 8 cases and 25 controls were evaluated. The 8 cases had a mean age of 44 years (range, 27–64 years). Years of death ranged from 2000 to 2013. Years of HIV diagnosis ranged from 1989 to 1996. The mean number of years living with HIV (until death) was 12 years (range, 1–19 years).

Fresh frozen cerebellar samples from 8 cases and 12 controls were evaluated. The 8 cases correspond to the subjects used in data set 2.

Peripheral blood mononuclear cells (PBMCs) isolated from 92 subjects were evaluated. The 24 cases had a mean age of 49 years (range, 29–67 years). The cases were from the National Neurological AIDS Bank study or Multicenter AIDS Cohort Study in Los Angeles. Informed consent and all study procedures were approved by the University of California–Los Angeles Medical IRB. The 68 controls had a mean age of 36 years (range, 18–74 years). The controls were nonmedicated subjects from a previously published study (GSE41169) [ 19 ]. DNA methylation data from cases and controls were generated by the same core facility.

If an issue is very vague, can you help narrow it down to something more specific? Maybe you can provide additional information to help reproduce a bug, or help by eliminating needless steps that aren't required to demonstrate the problem.

If you find a bug report without a test, it's very useful to contribute a failing test. This is also a great way to get started exploring the source code: looking at the existing test files will teach you how to write more tests. New tests are best contributed in the form of a patch, as explained later on in the " Snap Shirt Kenneth Cole Reaction For Nice For Sale Sneakernews Online Many Styles gkF3k
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Anything you can do to make bug reports more succinct or easier to reproduce helps folks trying to write code to fix those bugs - whether you end up writing the code yourself or not.

You can also help out by examining pull requests that have been submitted to Ruby on Rails via GitHub. In order to apply someone's changes, you need to first create a dedicated branch:

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After applying their branch, test it out! Here are some things to think about:

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I like the way you've restructured that code in generate_finder_sql - much nicer. The tests look good too.

If your comment simply reads "+1", then odds are that other reviewers aren't going to take it too seriously. Show that you took the time to review the pull request.

Ruby on Rails has two main sets of documentation: the guides, which help you learn about Ruby on Rails, and the API, which serves as a reference.

You can help improve the Rails guides by making them more coherent, consistent, or readable, adding missing information, correcting factual errors, fixing typos, or bringing them up to date with the latest edge Rails.

To do so, make changes to Rails guides source files (located on GitHub). Then open a pull request to apply your changes to master branch.

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To help our CI servers you should add [ci skip] to your documentation commit message to skip build on that commit. Please remember to use it for commits containing only documentation changes.

We are happy to have people volunteer to translate the Rails guides. Just follow these steps:

Note that translations are not submitted to the Rails repository. As detailed above, your work happens in a fork. This is so because in practice documentation maintenance via patches is only sustainable in English.

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